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Representative recording from a DRN 5-HT neuron (A) and the effect of <t>BLU9931</t> on the (B) density of the spontaneously active neurons, their mean firing rate (C) , frequency of burst firing (D) , percentage of spikes occurring in bursts (E) and mean number of spikes per burst (F) in male rats; **p < 0.01 in comparison with the vehicle-treated controls, two-tailed Student’s t-test.
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Representative recording from a DRN 5-HT neuron (A) and the effect of <t>BLU9931</t> on the (B) density of the spontaneously active neurons, their mean firing rate (C) , frequency of burst firing (D) , percentage of spikes occurring in bursts (E) and mean number of spikes per burst (F) in male rats; **p < 0.01 in comparison with the vehicle-treated controls, two-tailed Student’s t-test.
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Representative recording from a DRN 5-HT neuron (A) and the effect of <t>BLU9931</t> on the (B) density of the spontaneously active neurons, their mean firing rate (C) , frequency of burst firing (D) , percentage of spikes occurring in bursts (E) and mean number of spikes per burst (F) in male rats; **p < 0.01 in comparison with the vehicle-treated controls, two-tailed Student’s t-test.
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Representative recording from a DRN 5-HT neuron (A) and the effect of <t>BLU9931</t> on the (B) density of the spontaneously active neurons, their mean firing rate (C) , frequency of burst firing (D) , percentage of spikes occurring in bursts (E) and mean number of spikes per burst (F) in male rats; **p < 0.01 in comparison with the vehicle-treated controls, two-tailed Student’s t-test.
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Representative recording from a DRN 5-HT neuron (A) and the effect of <t>BLU9931</t> on the (B) density of the spontaneously active neurons, their mean firing rate (C) , frequency of burst firing (D) , percentage of spikes occurring in bursts (E) and mean number of spikes per burst (F) in male rats; **p < 0.01 in comparison with the vehicle-treated controls, two-tailed Student’s t-test.
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Representative recording from a DRN 5-HT neuron (A) and the effect of <t>BLU9931</t> on the (B) density of the spontaneously active neurons, their mean firing rate (C) , frequency of burst firing (D) , percentage of spikes occurring in bursts (E) and mean number of spikes per burst (F) in male rats; **p < 0.01 in comparison with the vehicle-treated controls, two-tailed Student’s t-test.
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Representative recording from a DRN 5-HT neuron (A) and the effect of BLU9931 on the (B) density of the spontaneously active neurons, their mean firing rate (C) , frequency of burst firing (D) , percentage of spikes occurring in bursts (E) and mean number of spikes per burst (F) in male rats; **p < 0.01 in comparison with the vehicle-treated controls, two-tailed Student’s t-test.

Journal: Frontiers in Pharmacology

Article Title: Fibroblast growth factor 2 (FGF2) modulates the excitability of brain noradrenergic and serotonergic neurons: possible involvement of FGFR1 and FGFR4 receptors

doi: 10.3389/fphar.2026.1875046

Figure Lengend Snippet: Representative recording from a DRN 5-HT neuron (A) and the effect of BLU9931 on the (B) density of the spontaneously active neurons, their mean firing rate (C) , frequency of burst firing (D) , percentage of spikes occurring in bursts (E) and mean number of spikes per burst (F) in male rats; **p < 0.01 in comparison with the vehicle-treated controls, two-tailed Student’s t-test.

Article Snippet: Selective antagonists of the receptors FGFR2 (lirafugratinib) ( ) and FGFR4 (BLU9931) ( ) were purchased from MedChemExpress (Monmouth Junction, NJ, United States).

Techniques: Comparison, Two Tailed Test